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Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications.
Activated ALK and ROS1 tyrosine kinases, resulting from chromosomal rearrangements, occur in a subset of non-small cell lung cancers (NSCLC) as well as other tumor types and their oncogenic relevance as actionable targets has been demonstrated by the efficacy of selective kinase inhibitors such as crizotinib, ceritinib, and alectinib. More recently, low-frequency rearrangements of TRK kinases h...
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The generation and transmission of the information in the central nervous system (CNS) strongly rely on the structural and functional framework formed by neuronal cells. However, astrocytes, the major glial cell type, may profoundly impact on the performance of the framework, as they give metabolic and trophic support to neurons, and regulate synapse formation and function. Under pathological s...
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Copyright: © 2006 Janet S. Duerr. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. To whom correspondence should be addressed. E-mail: [email protected] Immunohistochemistry* Janet S. Duerr, Department of Biologic...
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Despite growing evidence that increased brain-derived neurotrophic factor (BDNF) and hippocampal adult neurogenesis are necessary for the behavioral actions of antidepressants in rodents, the cellular mechanisms involved in these effects are still unknown. Li et al. in this issue of Neuron demonstrate that the presence of TrkB, the high-affinity receptor for BDNF, in hippocampal neural progenit...
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Target-derived neurotrophins like nerve growth factor (NGF) mediate biological effects by binding to and activating Trk neurotrophin receptors at nerve terminals. The activated Trk receptors then stimulate local effects at nerve terminals, and retrograde effects at neuronal cell bodies that often reside at considerable distances from the terminals. However, the nature of the retrograde signal h...
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ژورنال
عنوان ژورنال: Archives of Pathology & Laboratory Medicine
سال: 2020
ISSN: 1543-2165,0003-9985
DOI: 10.5858/arpa.2020-0400-ra